
- +40 Attack Damage
- +30% Attack Speed
Cloud Stride: +5% Move Speed.
Bring it Down: Every third attack deals 120-160 () bonus physical damage (110-150 () for ranged champions), increased by 1% per 1% Health the target is missing, up to an increase of 70%.

- +10 Attack Damage
- +45 Move Speed.
Conversion: +7% Omnivamp.

- +30% Attack Speed
Surge: Gain 5% Move Speed.
Chaos: Gain 25 Attack Damage or 50 Ability Power (Adaptive).
Wrath: Attacks deal 30 magic damage but no longer Critical Strike. Fore every 1% Critical Strike Rate gained from items, your magic damage increases by 1.5, up to a max increase of 75 (reached at 50% Critical Rate).
Seething Strike: Attacks grant 8% Attack Speed, staking up to 4 times for a maximum of 32% Attack Speed). While fully stacked, every 3 attacks applies on-hit effects an additional 1 times.

- +25 Attack Damage
- +35% Attack Speed
Thirst: +10% Omni Vamp.
Ruined Strikes: Attacks deal bonus physical damage equal to 8.5% of the enemy's current Health on-hit. (Melee attacks deal 10%). Minion damage: 15. Max damage vs monsters: 60.
Drain: Hitting a champion with 3 attacks or abilities deals 30-100 bonus magic damage and steals 25% of their Move Speed for 2 seconds. (60s Cooldown)

- +40 Attack Damage
- +30% Attack Speed
Shadow: Attacks deal 35 bonus magic damage on-hit.
Juxtaposition: Alternate between Light and Dark on-hits when attacking. Light attacks grant 5-8 Armor and Magic Resist for 5 seconds on hit. Dark attacks grant 11% Armor Pen and 11% Magic Pen for 5 seconds on hit. Each on-hit effect stacks up to 3 times. While you have this item, bonus Armor Pen and Magic Pen granted by it is capped at 40%.

- +60 Armor
- +60 Magic Resistance
Endurance: Gain 1 stacks of Endurance every 1 seconds while in combat with enemy champions (max 5 stacks). At maximum stacks, gain 20% size, 20% Tenacity, and increase Armor by 30% and Magic Resistance by 30% until out of combat with champion.

Gain stackable Attack Speed when attacking enemy champions. Stacks up to 6 times. At max stacks, you gain bonus range and can exceed your Attack Speed cap. Each stack increases Attack Speed by 8 – 16% (melee) or 3 – 10% (ranged) for 6 seconds. At max stacks, gain 50 (melee) or 75 (ranged) Attack Distance.
Source: wildriftfire.com/rune-list (maintained by iTzSTU4RT, scraped 2026-05-18)

Attacks deal 6 (+ 8% Bonus Attack Damage) bonus adaptive damage to enemy champions.
Source: wildriftfire.com/rune-list (maintained by iTzSTU4RT, scraped 2026-05-18)

When an enemy has less than 40% health, deals 8% bonus adaptive damage.
Source: wildriftfire.com/rune-list (maintained by iTzSTU4RT, scraped 2026-05-18)

Gain 3% bonus attack speed when engaging in taking down monsters, enemy champions and minions, up to 20% at maximum stacks.
Source: wildriftfire.com/rune-list (maintained by iTzSTU4RT, scraped 2026-05-18)

Blocks damage from the next triggering champion attack and 2 more attacks.
Source: wildriftfire.com/rune-list (maintained by iTzSTU4RT, scraped 2026-05-18)
Source: [[Sources/web-pages/2026-05-26-wrmeta-vayne-build-7.1e|WR Meta]] · sampling: Diamond / Master / Challenger (Legendary tier).
Situational item swaps (explicit):
- Mortal Reminder — when enemy healing is high
- Berserker's Greaves instead of Gluttonous Greaves — depending on situation
- Quicksilver Enchant instead of Stasis Enchant — depends on playstyle and battlefield
Counters / threats: Caitlyn, Draven, Nilah

